Mounjaro vs. Ozempic Weight Loss Shots
July 3, 2024
GLP-1 receptor agonists like Ozempic (semaglutide), Mounjaro (tirzepatide), and Saxenda (liraglutide) have helped countless people lose significant weight and improve blood sugar control. But if you’re using one of these medications and have suddenly stopped losing weight, you’re not alone—and you’re not doing anything wrong.
Weight loss plateaus are common, even on powerful medications. Your body is adapting, which doesn’t mean your progress is over. Here’s what to do if the scale stops moving on a GLP-1.
1. Check Your Dosage
One of the most common reasons for a weight loss plateau is not being on the optimal dose of your medication.
- Are you still titrating up? Most GLP-1s start at a low dose to minimize side effects and gradually increase to a therapeutic level. If you’re still early in your dose escalation, weight loss may slow or stall until you reach a higher, effective dose.
- Talk to your provider: If you’ve been on the same dose for a while and your weight has plateaued, ask your doctor whether it’s time to increase it, if your body tolerates it.
2. Reevaluate Your Calorie Intake
GLP-1s are powerful appetite suppressants, but your body is clever. Over time, calorie intake can creep up, or your metabolism may slow as you lose weight.
- Log your food for a week. You may be eating more than you think, or not enough protein or fiber to stay full.
- Eat intentionally: Focus on lean protein, non-starchy vegetables, and healthy fats. Avoid “slippery” calories from snacks, liquid calories, and processed foods.
- Update your calorie needs: As your weight drops, your basal metabolic rate (BMR) decreases. What worked at 250 lbs won’t work at 200 lbs.
3. Move More (and Smarter)
GLP-1s can help you eat less, but they don’t build muscle or increase your calorie burn.
- Add resistance training: Lifting weights 2–3 times per week helps preserve lean muscle, which is key to keeping your metabolism healthy.
- Increase NEAT: Non-exercise activity thermogenesis (walking, standing, cleaning) makes a big difference. Aim for 7,000–10,000 steps daily if possible.
- Be patient with exercise: It may not lead to instant weight loss, but it prevents regain and improves overall health.
4. Don’t Ignore Sleep and Stress
Two silent plateau-causers: lack of sleep and chronic stress.
- Poor sleep impacts your hunger hormones (ghrelin and leptin), increasing cravings, even on GLP-1s.
- Stress raises cortisol, which promotes fat storage and drives emotional eating.
Fixing sleep and managing stress can restart weight loss without changing your food or exercise habits.
5. Understand Metabolic Adaptation
When you lose weight, your body tries to maintain homeostasis by lowering your metabolism. This is known as adaptive thermogenesis.
It’s not failure—it’s biology.
- You may need to reduce your calorie intake slightly or increase activity to account for this adjustment.
- In some cases, temporary “reverse dieting” (slowly increasing calories) or taking a maintenance break can help your metabolism reset.
6. Talk to Your Provider About Options
If you’ve made healthy changes and are still stuck, it might be time to adjust your medication strategy.
- Ask your provider whether you’re on the most effective GLP-1 for your needs. Some people respond better to tirzepatide (which also targets GIP) than semaglutide.
- In some cases, combining medications (like GLP-1 + metformin or an SGLT2 inhibitor) can offer added benefits.
7. Redefine Success
Weight plateaus are frustrating—but they’re not failure. Sometimes, your body is settling into a healthy new set point.
- Celebrate non-scale victories: better labs, energy, mobility, mental health.
- Weight loss isn’t always linear. A plateau is often followed by another drop—if you stay consistent.
New to GLP-1s or want to discuss weight loss plans Spruce offers?
